Hello Eric, I'm sorry to hear you're having trouble with SignalR and interface refreshes. Typically in these cases I recommend setting up the application pool so that it recycles nightly, which should help keep things running smoothly. Have you seen any errors or warnings in the event viewer that might point at issues with .NET, IIS, or SignalR (WebSockets)?
Kyle Kerst
IT Coordinator
SmarterTools Inc.
www.smartertools.com