Hi Christopher,
I see the domain warning when my gateway is set to Round Robin. However, I'm not able to replicate an issue with the Save button. What change did you make to the gateway? Do you perhaps have an invalid fields that need to be fixed first? (You can find out by placing your cursor in the Server Address field and tabbing through all fields on the page. If any inputs are invalid, this will force the red validation error to appear.)
Andrea Free
SmarterTools Inc.
877-357-6278
www.smartertools.com