I second Jorel's suggestion. If you can use the gateway configuration, it also simplifies things for the users. When using SMTP Accounts for each user, it would only really work when using the web mail interface, and the users would need to choose to send from the SMTP account for each message. Using the Gateway, it would work whether the users are sending from the web interface or from a client, and it would be seamless to the users.
Andrew Barker
Software Developer
SmarterTools Inc.
www.smartertools.com