HI !
1) Are you using a Firewall in front of the 2022 server, or is the 2022 servers exposed directly to a public IP Address ? If you are using a firewall then do you have the ports open in that firewall ? If you do not have a firewall, I would recommend pfSense in front of that server.
2) Just FYI, When Zach is referring to a "site" he is talking about the "sites" inside of the IIS Settings. When I first heard sites i thought they were talking about websites. When Smarter Mail is installed, you may have to manually create an IIS "Site" called "webmail" or "SmarterMail". On our server with an older version of SmarterMail, the "Sites" were not automatically created and i had to manually create them.
www.HawaiianHope.org - Providing technology services to non profit organizations, low income families, homeless shelters, clean and sober houses and prisoner reentry programs. Since 2015, We have refurbished over 11,000 Computers !