Autodiscover is only for mailbox holders on your server to configure their client application to connect to your server and retrieve/send their email.
Autodiscover should have NO effect on outside mail servers and interaction such as exchanging mail with your server.
Things that affect communications between your server and others can include SPF, DKIM, DMARC, TLS connectivity, and your server's reputation on outside block lists or reputation regarding spam and abuse.
MailEnable survivor / convert --