When using the MSI you will have to create the website yourself. The MSI is more for setups needing to use msi, if your just updating, and we use them sometimes because they run faster, however it does not perform any IIS configuration. We haven't had any reported issues with the installer. We've had some false positive detections in some AV's for our older builds. Newer builds don't have these false detections. I wonder if maybe an AV removed or prevented that .cab file's execution?
EDIT: To create the website yourself, open IIS Manager.
-Add AppPool called SmarterMail, default options.
-Create site, SmarterMail, Select AppPool, Select the Physical path normally: C:\Program Files (x86)\SmarterTools\SmarterMail\MRS
-You should be able to connect locally from that machine to localhost:80, make sure to open any ports etc.
Matt Petty
Senior Software Developer
SmarterTools Inc.
www.smartertools.com