Hey Christopher,
I believe you'll need to set the folder auto-clean rule on a per user basis for any of the non-default folders. The specific user will have to login and navigate to filtering, folder auto-clean, and override the settings for their account. From there they should be able to select their specific folders and apply the auto-clean rule. I don't believe you can do this at the domain level.
Hope this helps.
Larry Duran
Software Developer
SmarterTools Inc.
www.smartertools.com