It's not possible to have 2 SmarterMail installations on the same server. I'm curious as to why you'd want to do that, even with Plesk Panel? SmarterMail is multi-tenant and can handle many, many domains with a single installation. Therefore, there's not a real need for having 2 different installations running.
Derek Curtis
COO
SmarterTools Inc.
www.smartertools.com