The built-in webservcie of SmarterMail tries to bind http ports 80 and 443 that are already used by your apache2 process:
Oct 12 05:59:54 server-10* MailService[661]: [WebServer] Listening on port 80 and 443
Also in your lsof I see that exim is running, which is a mail service, so it also binds on the port required for SmarterMail:
exim4 595 Debian-exim 4u IPv6 1682776854 0t0 TCP localhost:smtp (LISTEN)
I would stop these services and then restart SmarterMail.
systemctl stop apache2
systemctl stop exim4
systemctl restart smartermail
Then check the status of smartermail
systemctl status smartermail
If everything is running fine, you should disable automatic startup of apache2 and exim4
systemctl disable apache2
systemctl disable exim4
Hope this helps.
Sébastien Riccio
System & Network Admin
https://swisscenter.com