You need to open a ticket and probabily the tecnicians need to look at you VM network configurations.
I think there's something wrong with your SmarterMail config AND with the network config of your VM, but without accessing it directly and see it I cannot help you...
Sorry
Gabriele Maoret - Head of SysAdmins at SERSIS
Currently manages 6 SmarterMail installations (1 in the cloud for SERSIS which provides services to a few hundred third-party email domains + 5 on-premise for customers who prefer to have their mail server in-house)