We'll be releasing a minor soon that will fix this and other reported issues relating to Defender and domains failing to load. This error is printed because it's attempting to run the Defender checks (enabled in Antivirus) but it's not running on the machine. For now I'd recommend you not take any actions and wait for our update coming soon. The error being reported above does not negatively impact the delivery being made and the other virus checks will continue to check as normal.
Matt Petty
Senior Software Developer
SmarterTools Inc.
www.smartertools.com