Hello, 
At this time you can not send from a single domain over multiple IP's. This is a domain level setting.  As a possible work around you could add a domain with a sub domain to the server. 
- Main domain = domain.tld
 - Sub domain = mailingList.domain.tld
 
Have the users post to the mailingList sub domain and you can have SmarterMail route anything for that other site through a separate IP address or a separate gateway. 
Thank you
 
								Tony Scholz
System/Network Administrator
SmarterTools Inc.
www.smartertools.com