This is typically the response that comes from the mail server you are sending to. Unfortunately, we can't determine their cause for blocking the connections. You might try reaching out to the administrator of the domain you're trying to reach. As we discussed on the phone, here are the other resources you wanted to review: 

 

 

If you continue to have trouble with this, I'd encourage you to submit a ticket to the Support Department for their direct review. Until Nov 30th, technical support tickets can be purchased at 50% off. 

I always check the logs first.

- What does your SMTP logs look like for that day and the email address in question, with details.

- Have you checked the your domain and the other domain against mxtoolbox.com  There could be a problem at the end.

- The other thing I have run into check your blacklisted IPs (IDS blocks) make sure there is nothing in there.  I occasionally get an SMTP IP blocked.