ellisfr  Found the fix for this in his thread: https://portal.smartertools.com/community/a89049/cant-access-log-folder-in-sm-16.aspx

 

You need to add IIS_IUSRS in the permission of your E:\SmarterMail\Logs folder. Read access should be enough.

That fixed it for me..... it seems that my data folder being on another drive had nothing to do with this error as default locations were still not accessible and the IIS process had to be added to the folder security.

Thanks for the help Mathew..