We have noticed an issue in chrome that some of our users are seeing when trying to reply or forward some e-mails that they have gotten from specific customers. They would type the e-mail up and when they hit the "send" button the send button will go gray for a couple of seconds and then go blue again. The e-mail pane never closes and the e-mail never sends. If they switched over to Internet explorer, even if they saved it as a draft so it is the exact same e-mail, it would work, and send as expected. After some research I have identified the problem is the base tag in html. For example: <base href="https://website/" target="_self">. If I go to code view when editing the reply or forward and remove the word "base" (so it would leave: <href="https://website/" target="_self">)  and then try to send it will work in chrome.