Hi Shahab. This error is probably coming from the server that you are trying to send to. Usually 451 errors happen when the receiving server rejects your mail. It can happen for a few different reasons but more than likely it's the recipients server being overloaded with mail. Alternatively, it can be the recipients mail server has graylisted your IP. Can you contact the recipient in a different way and ask him if his ESP can check their logs to see what's going on?