OK, fixed it I think.

In the following folder:

Program Files (x86) > SmarterTools > SmarterMail > Service > Clam > Share > ClamAV > 

 

Stop the smartermail service first.

Rename the file in the folder above: daily.cvd to something else.

 

Restart the service.

Once its renewed the AV definitions, things should be working.

 

This worked for me.

Hello, sorry about the no response, But I'm glad you got it figured out and posted the answer, hopefully others who may have this issue can also spot this out.

Well it lasted a week, now failing again...

A snippet from the log file:

Tue Jul 05 18:24:44 2016 -> +++ Started at Tue Jul 05 18:24:44 2016
Tue Jul 05 18:24:44 2016 -> clamd daemon 0.97.6 (OS: win32, ARCH: i386, CPU: i386)
Tue Jul 05 18:24:44 2016 -> Log file size limited to 1048576 bytes.
Tue Jul 05 18:24:44 2016 -> Reading databases from C:\PROGRA~2\SMARTE~1\SMARTE~1\Service\Clam\share\clamav
Tue Jul 05 18:24:44 2016 -> Not loading PUA signatures.
Tue Jul 05 18:24:44 2016 -> Bytecode: Security mode set to "TrustSigned".
Tue Jul 05 18:24:45 2016 -> ERROR: Malformed database
Log size = 1048628, max = 1048576
LOGGING DISABLED (Maximal log file size exceeded).
Log size = 1048715, max = 1048576
LOGGING DISABLED (Maximal log file size exceeded).

Renamed above file in my instructions and its running again.

I don't really want to be doing this every week, how do i stop it dying?