cd,
The first place I would look is SECURITY > ADVANCED SETTINGS > SMTP BLOCKING. You may have some wildcard entries that are causing all email to fail.
Then, double-check your SECURITY > BLACKLIST to make sure that there aren't any inclusive IP Ranges.
Lastly, under SECURITY > ANTISPAM ADMINISTRATION check your SMTP BLOCKING to see what you have set for your INCOMING WEIGHT THRESHOLD. If you have any single Antispam checks that exceed that weight check to make sure that they are providing a legitimate response (often when an RBL rate-limits you or blocks you the response is the same as a failed lookup, providing you with 100% false-positives). If you are indeed getting back only failures then disable that Antispam check and click [SAVE].
Note: If you have your SMTP Logs set to "Detailed" they will tell you which of these mechanisms is causing the 554 response.