Some servers out there are really slow to respond to RCPT command...
This can cause a generic 601 ERROR
My advice is to set the two timeouts to 600 seconds.
Gabriele Maoret - Head of SysAdmins at SERSIS
Currently manages 6 SmarterMail installations (1 in the cloud for SERSIS which provides services to a few hundred third-party email domains + 5 on-premise for customers who prefer to have their mail server in-house)