It is possible to have an option for Autoresponder to include sender's subject.
Something like; Out of Office; RE <Subject>
As are having issues where users log a ticket via our helpdesk using email and have set their Autoresponder
1. One of our agents replies to the ticket
2. Autoresponder replies to the ticket helpdesk
3. Helpdesk system opens a new ticket as the email subject it does not contain a reference to the ticket number which it uses to associate the email to the ticket.