For the second time in a year we had a domain we host have a user with a trojan on their personal computer sending tens of thousands of emails causing us to get blocked by Comcast and AT&T which took forever to resolve.  I put in place throttles for messages per hour but has anyone published a useful document on outbound message processing rules to protect domains from issues such as this? We have great articles on anti-spam settings and how to keep our INBOXES healthy but has anyone considered or know of good articles on outbound configurations to keep our reputations in good standing? I'd love to see should anyone care to publish or link to an article such as this.